Publications

CLICK HERE for a FULL LIST of our publications at NCBI

Recent Publications:

Hoffman JL, Faccidomo SP, Taylor SM, DeMiceli KG, May AM, Smith EN, Whindleton CM, and Hodge CW. Negative modulation of AMPA receptors bound to transmembrane AMPA receptor regulatory protein γ-8 blunts the positive reinforcing properties of alcohol and sucrose in a brain region-dependent manner in male mice. Psychopharmacology, 4/6/2023; in press. Publisher’s online link: https://rdcu.be/c9R8i

Hoffman JL, Faccidomo S, Saunders BL, Taylor SM, Kim M, Hodge CW. Inhibition of AMPA receptors (AMPARs) containing transmembrane AMPAR regulatory protein γ-8 with JNJ-55511118 shows preclinical efficacy in reducing chronic repetitive alcohol self-administration. Alcohol Clin Exp Res. 2021 Jun 4. doi: 10.1111/acer.14639. Online ahead of print.PMID: 34086361

Faccidomo S, Cogan ES, Hon OJ, Hoffman JL, Saunders BL, Eastman VR, Kim M, Taylor SM, McElligott ZA, Hodge CW. Calcium-permeable AMPA receptor activity and GluA1 trafficking in the basolateral amygdala regulate operant alcohol self-administration. Addict Biol. 2021 May 5;:e13049. doi: 10.1111/adb.13049. [Epub ahead of print] PubMed PMID: 33955100.

Hoffman JL*, Faccidomo S*, Kim M, Taylor SM, Agoglia AE, May AM, Smith EN, Wong LC, Hodge CW. Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer’s disease. Int Rev Neurobiol. 2019;148:169-230. doi: 10.1016/bs.irn.2019.10.017. Epub 2019 Oct 23. Review. PubMed PMID: 31733664; PubMed Central PMCID: PMC6939615. * – co-first authors.

Faccidomo, S., S. E. Holstein, T. S. Santanam, B. L. Saunders, K. S. Swaim, G. T. Reid, C. O’Neill, V. R. Eastman, and C. W. Hodge. “Pharmacological Inhibition of Glycogen Synthase Kinase 3 Increases Operant Alcohol Self-Administration in a Manner Associated with Altered Pgsk-3beta, Protein Interacting with C Kinase and Glua2 Protein Expression in the Reward Pathway of Male C57bl/6j Mice.” Behav Pharmacol  (Sep 9 2019). https://doi.org/10.1097/FBP.0000000000000501. https://www.ncbi.nlm.nih.gov/pubmed/31503067.

Stevenson, R. A., J. L. Hoffman, A. M. Maldonado-Devincci, S. Faccidomo, and C. W. Hodge. “Mglur5 Activity Is Required for the Induction of Ethanol Behavioral Sensitization and Associated Changes in Erk Map Kinase Phosphorylation in the Nucleus Accumbens Shell and Lateral Habenula.” Behav Brain Res 367 (Jul 23 2019): 19-27. https://doi.org/10.1016/j.bbr.2019.03.038. https://www.ncbi.nlm.nih.gov/pubmed/30914307.

Faccidomo, S., K. S. Swaim, B. L. Saunders, T. S. Santanam, S. M. Taylor, M. Kim, G. T. Reid, V. R. Eastman, and C. W. Hodge. “Mining the Nucleus Accumbens Proteome for Novel Targets of Alcohol Self-Administration in Male C57bl/6j Mice.” Psychopharmacology (Berl) 235, no. 6 (Jun 2018): 1681-96. https://doi.org/10.1007/s00213-018-4870-3. https://www.ncbi.nlm.nih.gov/pubmed/29502276.

Agoglia, A. E., S. E. Holstein, A. T. Small, M. Spanos, B. M. Burrus, and C. W. Hodge. “Comparison of the Adolescent and Adult Mouse Prefrontal Cortex Proteome.” PLoS One 12, no. 6 (2017): e0178391. https://doi.org/10.1371/journal.pone.0178391. https://www.ncbi.nlm.nih.gov/pubmed/28570644.

Cannady, R., K. R. Fisher, C. Graham, J. Crayle, J. Besheer, and C. W. Hodge. “Potentiation of Amygdala Ampa Receptor Activity Selectively Promotes Escalated Alcohol Self-Administration in a Camkii-Dependent Manner.” Addict Biol 22, no. 3 (May 2017): 652-64. https://doi.org/10.1111/adb.12357.

https://www.ncbi.nlm.nih.gov/pubmed/26742808.

Salling, M. C., C. J. Hodge, K. E. Psilos, V. R. Eastman, S. P. Faccidomo, and C. W. Hodge. “Cue-Induced Reinstatement of Alcohol-Seeking Behavior Is Associated with Increased Camkii T286 Phosphorylation in the Reward Pathway of Mice.” Pharmacol Biochem Behav 163 (Dec 2017): 20-29.https://doi.org/10.1016/j.pbb.2017.10.011. https://www.ncbi.nlm.nih.gov/pubmed/29100991.

Salling, M. C., S. P. Faccidomo, C. Li, K. Psilos, C. Galunas, M. Spanos, A. E. Agoglia, T. L. Kash, and C. W. Hodge. “Moderate Alcohol Drinking and the Amygdala Proteome: Identification and Validation of Calcium/Calmodulin Dependent Kinase Ii and Ampa Receptor Activity as Novel Molecular Mechanisms of the Positive Reinforcing Effects of Alcohol.” Biol Psychiatry 79, no. 6 (Mar 15 2016): 430-42. https://doi.org/10.1016/j.biopsych.2014.10.020. https://www.ncbi.nlm.nih.gov/pubmed/25579851.

• Cover article with Featured image
• Featured commentary: Sean P. Farris, Moving Toward Understanding the Proteome Involved in Substance Abuse, Biological Psychiatry,79(6):422-424; 2016

Agoglia, A. E., S. E. Holstein, V. R. Eastman, and C. W. Hodge. “Cannabinoid Cb1 Receptor Inhibition Blunts Adolescent-Typical Increased Binge Alcohol and Sucrose Consumption in Male C57bl/6j Mice.” Pharmacol Biochem Behav 143 (Apr 2016): 11-7. https://doi.org/10.1016/j.pbb.2016.01.009. https://www.ncbi.nlm.nih.gov/pubmed/26800788.

Faccidomo, S., G. T. Reid, A. E. Agoglia, S. A. Ademola, and C. W. Hodge. “Camkii Inhibition in the Prefrontal Cortex Specifically Increases the Positive Reinforcing Effects of Sweetened Alcohol in C57bl/6j Mice.” Behav Brain Res 298, no. Pt B (Feb 1 2016): 286-90. https://doi.org/10.1016/j.bbr.2015.11.018. https://www.ncbi.nlm.nih.gov/pubmed/26608538.

Faccidomo, S., M. C. Salling, C. Galunas, and C. W. Hodge. “Operant Ethanol Self-Administration Increases Extracellular-Signal Regulated Protein Kinase (Erk) Phosphorylation in Reward-Related Brain Regions: Selective Regulation of Positive Reinforcement in the Prefrontal Cortex of C57bl/6j Mice.” Psychopharmacology (Berl) 232, no. 18 (Sep 2015): 3417-30.https://doi.org/10.1007/s00213-015-3993-z. https://www.ncbi.nlm.nih.gov/pubmed/26123321.

Agoglia, A. E., A. C. Sharko, K. E. Psilos, S. E. Holstein, G. T. Reid, and C. W. Hodge. “Alcohol Alters the Activation of Erk1/2, a Functional Regulator of Binge Alcohol Drinking in Adult C57bl/6j Mice.” Alcohol Clin Exp Res 39, no. 3 (Mar 2015): 463-75. https://doi.org/10.1111/acer.12645. https://www.ncbi.nlm.nih.gov/pubmed/25703719.